For more than a decade, DIANA-Lab aims to cater to the non-coding RNA (ncRNA) community, by providing algorithms, databases and web-servers for the systematic archiving and interpretation of ncRNA-related biological data. The laboratory’s scientific interests range from the cataloguing and manual annotation of experimentally supported miRNA targets and gene regulatory elements to the interpretation of ncRNA involvement in diseases and the identification of tissue- and condition-specific regulatory events of importance. DIANA-Lab excels at the pre-processing and analysis of datasets from various Next Generation Sequencing techniques, (e.g. small RNA-Seq, RNA-Seq, HITS-CLIP, PAR-CLIP, DNase-Seq, CAGE), as well as the integration of such data towards the development of innovative machine learning predictive models.
The arsenal of DIANA-Tools currently includes miRNA target prediction algorithms, applications for the identification of miRNA Transcription Start Sites and miRNA-TF interactions, tools for analysis of CLIP-Seq experiments, databases of experimentally verified miRNA targets on coding and non-coding RNAs, a web-server for online functional explorations of the effects a single or multiple expressed miRNAs can have on molecular pathways and a web-server enabling the combined analysis of RNA-Seq and small RNA-Seq experiments to identify important regulators. Additionally, DIANA-web server supports a series of workflows that enable users lacking bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses.
DIANA-Lab is affiliated with the Department of Computer Science and Biomedical Informatics of the University of Thessaly (UTH) and its collaborators include Hellenic Pasteur Institute (HPI) and the Information Management Systems Institute (IMSI) of ‘Athena’ Research Center.
13-September-2023: Diana Tools are back online!
6-September-2023: Diana Tools temporarily offline due to severe weather conditions in central Greece
3-November-2021: DianaLab is up to date!
20-December-2020: Publication is up to date!
20-November-2020: Diana – miRGen v4 Database is accepted for publication in Nucleic Acid Research 2021 Database Issue
16-November-2020: Peryton Database is accepted for publication in Nucleic Acid Research 2021 Database Issue
05-November-2018: Dianalab.gr is up!!