Peryton constitutes a novel resource of experimentally supported microbe-disease associations, currently hosting more than 7,900 entries linking 43 diseases and 1,396 microorganisms. Peryton’s content is exclusively sustained by manual curation of biomedical articles. Importantly, diseases and microorganisms are provided in a systematic, standardized manner using reference resources to create database dictionaries. Information about the experimental design, study cohorts and the applied high- or low-throughput techniques are meticulously annotated and catered to users.